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Keep track of Carefully (one)pentobarbital will lessen the level or outcome of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to your minimize in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, improvement of the with